With about 66,000 public school students (2011–12), the Detroit Public Schools (DPS) district is the largest school district in Michigan. Detroit has an additional 56,000 charter school students for a combined enrollment of about 122,000 students.

In the mid-to-late 1990s, the Michigan Legislature removed the locally elected board of education amid allegations of mismanagement and replaced it with a reform board appointed by the mayor and governor. The elected board of education was re-established following a city referendum in 2005. The first election of the new 11-member board of education occurred on November 8, 2005 Due to growing Detroit Charter Schools enrollment, the city planned to close many public schools. State officials report a 68% graduation rate for Detroit's public schools adjusted for those who change schools.Public and charter school students in the city have had mixed results on standardized tests.

Detroit is served by various private schools, as well as parochial Roman Catholic schools operated by the Archdiocese of Detroit. The Archdiocese of Detroit lists a number of primary and secondary schools in the city, along with those in the metro area as Catholic education has emigrated to the suburbs.^] There are 23 Catholic high schools in the Archdiocese of Detroit.Of the three Catholic high schools in the city, two are operated by the Society of Jesus and the third is co-sponsored by the Sisters, Servants of the Immaculate Heart of Mary and the Congregation of St. Basil.

Detroit is home to several institutions of higher learning including Wayne State University, a national research university with medical and law schools in the Midtown area offering hundreds of academic degrees and programs. The University of Detroit Mercy, located in Northwest Detroit in the University District, is a prominent Roman Catholic co-educational university affiliated with the Society of Jesus (the Jesuits) and the Sisters of Mercy. The University of Detroit Mercy offers more than a hundred academic degrees and programs of study including business, dentistry, law, engineering, architecture, nursing and allied health professions. The University of Detroit Mercy School of Law is located Downtown across from the Renaissance Center. Other institutions in the city include the College for Creative Studies, Lewis College of Business, Marygrove College and Wayne County Community College. In June 2009, the Michigan State University College of Osteopathic Medicine which is based in East Lansing opened a satellite campus located at the Detroit Medical Center. The University of Michigan was established in 1817 in Detroit and later moved to Ann Arbor in 1837. In 1959, University of Michigan–Dearborn was established in neighboring Dearborn.